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Ighg2cem2Wliu
Endonuclease-mediated Allele Detail
Summary
Symbol: Ighg2cem2Wliu
Name: immunoglobulin heavy constant gamma 2C; endonuclease-mediated mutation 2, Wanli Liu
MGI ID: MGI:7627371
Synonyms: mIgG2c-tailless
Gene: Ighg2c  Location: Chr12:113251009-113252552 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance: Ighg2cem2Wliu page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 technology generated a truncation of the cytoplasmic tail of the membrane-bound Ighg2c heavy chain. (J:322180)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ighg2c Mutation:  16 strains or lines available
References
Original:  J:322180 Yang B, et al., An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. J Clin Invest. 2022 Mar 15;132(6):e153454
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory