Fmo1^em1Anz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fmo1^em1Anz
• Name: flavin containing monooxygenase 1; endonuclease-mediated mutation 1, Zhuoling An
• MGI ID: MGI:7628220
• Gene: Fmo1 Location: Chr1:162657130-162694170 bp, - strand Genetic Position: Chr1, 70.34 cM, cytoband H1
• Alliance: Fmo1^em1Anz page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting exons 3-4 created a null allele. Expression analysis confirmed the absence of mRNA in brains from homozygous mice. (J:312983)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmo1 Mutation: 40 strains or lines available

References

• Original: J:312983 Li B, et al., Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice. Neurosci Lett. 2021 Nov 1;764:136222
• All: 1 reference(s)