Tcf25^em1Xdzg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tcf25^em1Xdzg
• Name: transcription factor 25 (basic helix-loop-helix); endonuclease-mediated mutation 1, Xiao-Dong Zhang
• MGI ID: MGI:7628233
• Gene: Tcf25 Location: Chr8:124100492-124130574 bp, + strand Genetic Position: Chr8, 72.1 cM
• Alliance: Tcf25^em1Xdzg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9 mediated recombination using guide RNAs targeting exon 1 created an 11 bp deletion. (J:317382)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf25 Mutation: 30 strains or lines available

References

• Original: J:317382 Zhang X, et al., NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3 Transcriptional Activity. J Am Heart Assoc. 2020 Aug 18;9(16):e016419
• All: 1 reference(s)