Thbs4^tm1Olsa
Targeted Allele Detail

Summary

• Symbol: Thbs4^tm1Olsa
• Name: thrombospondin 4; targeted mutation 1, Olga Stenina-Adognravi
• MGI ID: MGI:7628361
• Synonyms: mutTSP-4 KI, P387 TSP-4 KI, TSP4-P387-KI
• Gene: Thbs4 Location: Chr13:92888098-92931326 bp, - strand Genetic Position: Chr13, 47.75 cM
• Alliance: Thbs4^tm1Olsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301119
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Alanine codon 389 (GCG) in exon 9 was changed to proline (CCG) (p.A389P). The mutation is the equivalent of the human p.A387P mutation associated with myocardial infarction (MI) and coronary artery disease (CAD). (J:301119)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbs4 Mutation: 68 strains or lines available

References

• Original: J:301119 Muppala S, et al., Proangiogenic Properties of Thrombospondin-4. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1975-86
• All: 3 reference(s)