Cpne7^tm1Parkj
Targeted Allele Detail

Summary

• Symbol: Cpne7^tm1Parkj
• Name: copine VII; targeted mutation 1, Joo-Cheol Park
• MGI ID: MGI:7628719
• Gene: Cpne7 Location: Chr8:123844113-123861921 bp, + strand Genetic Position: Chr8, 72.06 cM
• Alliance: Cpne7^tm1Parkj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:347866
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region spanning exons 5-7 was replaced with an EGFP gene and neo cassette via homologous recombination. Immunohistochemical analysis confirmed the loss of expression in dental pulp cells from homozygous mice at 1 month of age. (J:347866)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpne7 Mutation: 26 strains or lines available

References

• Original: J:347866 Lee YS, et al., Cpne7 deficiency induces cellular senescence and premature aging of dental pulp. Aging Cell. 2024 Mar;23(3):e14061
• All: 1 reference(s)