Son^em1.1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Son^em1.1Bcgen
• Name: Son DNA binding protein; endonuclease-mediated mutation 1.1, Biocytogen LLC
• MGI ID: MGI:7638800
• Gene: Son Location: Chr16:91444712-91476080 bp, + strand Genetic Position: Chr16, 53.22 cM
• Alliance: Son^em1.1Bcgen page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites via CRISPR/Cas9 technology. Exon 2 was then deleted via cre-mediated recombination in the germline. Deletion of exon 2 causes a premature stop codon after encoding 9 amino acids in exon 3. (J:347709)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Son Mutation: 121 strains or lines available

References

• Original: J:347709 Vukadin L, et al., A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis. JCI Insight. 2024 Mar 8;9(5)
• All: 1 reference(s)