Cdh2^tm1.1Ayki
Targeted Allele Detail

Summary

• Symbol: Cdh2^tm1.1Ayki
• Name: cadherin 2; targeted mutation 1.1, Ayae Kinoshita
• MGI ID: MGI:7639718
• Synonyms: Cdh2^{R714G, I715D}
• Gene: Cdh2 Location: Chr18:16721934-16942303 bp, - strand Genetic Position: Chr18, 10.1 cM
• Alliance: Cdh2^tm1.1Ayki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302799
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Arginine codon (AGG) in exon 13 was changed to glycine (GGG) (p.R714G) and isoleucine codon (ATC) was changed to aspartic acid (GAT) (p.I715D). A loxP site flanked neomycin resistance gene cassette was inserted into intron 13 and subsequently removed through Cre-mediated recombination. The mutations renders the encoded peptide resistant to proteolytic cleavage by Adam10. (J:302799)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh2 Mutation: 51 strains or lines available

References

• Original: J:302799 Asada-Utsugi M, et al., Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks. Mol Brain. 2021 Jan 25;14(1):23
• All: 1 reference(s)