Pinlyp^em1Liax
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pinlyp^em1Liax
• Name: phospholipase A2 inhibitor and LY6/PLAUR domain containing; endonuclease-mediated mutation 1.1, Xiaozhen Liang
• MGI ID: MGI:7639784
• Synonyms: PINLYP^-92
• Gene: Pinlyp Location: Chr7:24241083-24245543 bp, - strand Genetic Position: Chr7, 11.38 cM
• Alliance: Pinlyp^em1Liax page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs created a 92 bp deletion including parts of exon 1 and exon 2. (J:322222)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pinlyp Mutation: 16 strains or lines available

References

• Original: J:322222 Liu Z, et al., Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2111115119
• All: 1 reference(s)