Lpcat1^tm1.1Tksh
Targeted Allele Detail

Summary

• Symbol: Lpcat1^tm1.1Tksh
• Name: lysophosphatidylcholine acyltransferase 1; targeted mutation 1.1, Takao Shimizu
• MGI ID: MGI:7639813
• Synonyms: LPCAT1-KO
• Gene: Lpcat1 Location: Chr13:73615332-73664539 bp, + strand Genetic Position: Chr13, 39.97 cM
• Alliance: Lpcat1^tm1.1Tksh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215466
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site and FRT flanked pgk-neo cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. Cre-mediated recombination in the germline resulted in the deletion of exon 3 and the selection cassette. (J:215466)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpcat1 Mutation: 37 strains or lines available

References

• Original: J:215466 Harayama T, et al., Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo. Cell Metab. 2014 Aug 5;20(2):295-305
• All: 6 reference(s)