Firrm^em1.1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Firrm^em1.1Gpt
• Name: FIGNL1 interacting regulator of recombination and mitosis; endonuclease-mediated mutation 1.1, GemPharmatech
• MGI ID: MGI:7639967
• Synonyms: Flip^-
• Gene: Firrm Location: Chr1:163773562-163822365 bp, - strand Genetic Position: Chr1, 71.25 cM
• Alliance: Firrm^em1.1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-6 were flanked by loxP sites using CRISPR/Cas9 technology. Cre-mediated recombination removed exons 4 through 6. (J:344887)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Firrm Mutation: 50 strains or lines available

References

• Original: J:344887 Zhang Q, et al., The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart. Nucleic Acids Res. 2023 Sep 8;51(16):8606-8622
• All: 1 reference(s)