Mrgprx1^em1Cao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mrgprx1^em1Cao
• Name: MAS-related GPR, member X1; endonuclease-mediated mutation 1, Zhijian Cao
• MGI ID: MGI:7639969
• Gene: Mrgprx1 Location: Chr7:47670719-47677345 bp, - strand Genetic Position: Chr7, 31.09 cM
• Alliance: Mrgprx1^em1Cao page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9 mediated recombination using a guide RNA created a 964 bp deletion in exon 2. (J:329699)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrgprx1 Mutation: 17 strains or lines available

References

• Original: J:329699 Li X, et al., Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors. J Allergy Clin Immunol. 2021 Jun;147(6):2236-2248.e16
• All: 1 reference(s)