Otub2^tm1.1Gpt
Targeted Allele Detail

Summary

• Symbol: Otub2^tm1.1Gpt
• Name: OTU domain, ubiquitin aldehyde binding 2; targeted mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:7640053
• Gene: Otub2 Location: Chr12:103354941-103372609 bp, + strand Genetic Position: Chr12, 52.92 cM
• Alliance: Otub2^tm1.1Gpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330595
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Cre mediated recombination removed exons 4 and 4 and the neo cassette. (J:330595)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otub2 Mutation: 22 strains or lines available

References

• Original: J:330595 Chang W, et al., OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis. Cell Rep. 2022 Oct 25;41(4):111561
• All: 1 reference(s)