Ms4a7^em1.1Jddl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ms4a7^em1.1Jddl
• Name: membrane-spanning 4-domains, subfamily A, member 7; endonuclease-mediated mutation 1, Jiandie D Lin
• MGI ID: MGI:7640119
• Gene: Ms4a7 Location: Chr19:11298403-11313510 bp, - strand Genetic Position: Chr19, 8.43 cM, cytoband B
• Alliance: Ms4a7^em1.1Jddl page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains the start of the coding region, was flanked by loxP sites via CRISPR/Cas9 technology. Cre-mediated recombination deleted exon 2. Western blot analysis confirmed the absence of protein in liver. (J:347975)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ms4a7 Mutation: 14 strains or lines available

References

• Original: J:347975 Zhou L, et al., Hepatic danger signaling triggers TREM2(+) macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation. Sci Transl Med. 2024 Mar 13;16(738):eadk1866
• All: 1 reference(s)