Kcne5^em1Mdcb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcne5^em1Mdcb
• Name: potassium voltage-gated channel subfamily E regulatory subunit 5; endonuclease-mediated mutation 1, Max-Delbrueck-Center for Molecular Medicine Berlin
• MGI ID: MGI:7641768
• Gene: Kcne5 Location: ChrX:141087749-141089194 bp, - strand Genetic Position: ChrX, 63.11 cM, cytoband F1
• Alliance: Kcne5^em1Mdcb page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: Zinc finger technology introduced three stop-codons (TGA) for every reading frame, as well as an exogenous Tfil restricition site. (J:283729)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcne5 Mutation: 3 strains or lines available

References

• Original: J:283729 David JP, et al., Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia. FASEB J. 2019 Feb;33(2):2537-2552
• All: 1 reference(s)