Dyrk1b^em1Yax
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dyrk1b^em1Yax
• Name: dual-specificity tyrosine phosphorylation regulated kinase 1b; endonuclease-mediated mutation 1, Xiaoxiang Yan
• MGI ID: MGI:7642198
• Gene: Dyrk1b Location: Chr7:27878894-27886719 bp, + strand Genetic Position: Chr7, 16.67 cM
• Alliance: Dyrk1b^em1Yax page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Talen mediated recombination created a 10 bp deletion in exon 4. (J:334531)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dyrk1b Mutation: 31 strains or lines available

References

• Original: J:334531 Zhuang L, et al., DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics. Circulation. 2022 Mar 15;145(11):829-846
• All: 1 reference(s)