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Il1r2tm1.1Mchc
Targeted Allele Detail
Summary
Symbol: Il1r2tm1.1Mchc
Name: interleukin 1 receptor, type II; targeted mutation 1.1, Murray CH Clarke
MGI ID: MGI:7643172
Synonyms: Il1r2fl
Gene: Il1r2  Location: Chr1:40123872-40164390 bp, + strand  Genetic Position: Chr1, 18.65 cM
Alliance: Il1r2tm1.1Mchc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:347877
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP and F3-flanked neomycin selection cassette was inserted upstream of exon 3 and an FRT-flanked puromycin selection cassette and second loxP site were inserted downstream of exon 3. Flp-mediated recombination removed the selection cassettes leaving exon 3 floxed. (J:347877)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il1r2 Mutation:  32 strains or lines available
References
Original:  J:347877 Pyrillou K, et al., Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1. JCI Insight. 2024 Feb 8;9(5):e174005
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory