About   Help   FAQ
Il1r2tm1.1Mchc
Targeted Allele Detail
Summary
Symbol: Il1r2tm1.1Mchc
Name: interleukin 1 receptor, type II; targeted mutation 1.1, Murray CH Clarke
MGI ID: MGI:7643172
Synonyms: Il1r2fl
Gene: Il1r2  Location: Chr1:40123872-40164390 bp, + strand  Genetic Position: Chr1, 18.65 cM
Alliance: Il1r2tm1.1Mchc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:347877
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP and F3-flanked neomycin selection cassette was inserted upstream of exon 3 and an FRT-flanked puromycin selection cassette and second loxP site were inserted downstream of exon 3. Flp-mediated recombination removed the selection cassettes leaving exon 3 floxed. (J:347877)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il1r2 Mutation:  32 strains or lines available
References
Original:  J:347877 Pyrillou K, et al., Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1. JCI Insight. 2024 Feb 8;9(5):e174005
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory