Il1r2^tm1.2Mchc
Targeted Allele Detail

Summary

• Symbol: Il1r2^tm1.2Mchc
• Name: interleukin 1 receptor, type II; targeted mutation 1.2, Murray CH Clarke
• MGI ID: MGI:7643174
• Synonyms: R2^-
• Gene: Il1r2 Location: Chr1:40123872-40164390 bp, + strand Genetic Position: Chr1, 18.65 cM
• Alliance: Il1r2^tm1.2Mchc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:347877
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP and F3-flanked neomycin selection cassette was inserted upstream of exon 3 and an FRT-flanked puromycin selection cassette and second loxP site were inserted downstream of exon 3. Flp-mediated recombination removed the selection cassettes. Exon 3 was deleted via cre-mediated recombination in the germline. (J:347877)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1r2 Mutation: 32 strains or lines available

References

• Original: J:347877 Pyrillou K, et al., Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1. JCI Insight. 2024 Feb 8;9(5):e174005
• All: 1 reference(s)