Adra2a^{tm1(cre/ERT2)Ddg}
Targeted Allele Detail

Summary

• Symbol: Adra2a^{tm1(cre/ERT2)Ddg}
• Name: adrenergic receptor, alpha 2a; targeted mutation 1, David D Ginty
• MGI ID: MGI:7643381
• Synonyms: Adra2a^T2a-CreER
• Gene: Adra2a Location: Chr19:54033690-54037413 bp, + strand Genetic Position: Chr19, 49.04 cM
• Alliance: Adra2a^{tm1(cre/ERT2)Ddg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:348651
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Adra2a^{tm1(cre/ERT2)Ddg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Adra2a (MGI:87934)

• Mutation details: The T2a-cre/ERT2 cassette followed by STOP and frt flanked neo cassette was inserted directly upstream of the stop codon in the last exon of the Adra2a gene. (J:348651)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Adra2a (mouse) Summary of all recombinase alleles driven by Adra2a. Alliance mouse Adra2a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adra2a Mutation: 28 strains or lines available

References

• Original: J:348651 Qi L, et al., A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell. 2024 Mar 14;187(6):1508-1526.e16
• All: 2 reference(s)