Nsd3^tm1.1Caox
Targeted Allele Detail

Summary

• Symbol: Nsd3^tm1.1Caox
• Name: nuclear receptor binding SET domain protein 3; targeted mutation 1.1, Xuetao Cao
• MGI ID: MGI:7643542
• Synonyms: NSD3^fl
• Gene: Nsd3 Location: Chr8:26091617-26209694 bp, + strand Genetic Position: Chr8, 14.17 cM
• Alliance: Nsd3^tm1.1Caox page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251909
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 16 and a loxP site was inserted downstream of exon 17. An FRT-flanked neomycin resistance gene was also inserted and removed via flp-mediated recombination. (J:251909)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nsd3 Mutation: 69 strains or lines available

References

• Original: J:251909 Wang C, et al., The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3. J Exp Med. 2017 Dec 4;214(12):3597-3610
• All: 1 reference(s)