Tg(Thy1-SNCA*)37Dett
Transgene Detail

Summary

• Symbol: Tg(Thy1-SNCA*)37Dett
• Name: transgene insertion 37, Ulf Dettmer
• MGI ID: MGI:7643547
• Synonyms: Thy1 3D alphaS
• Transgene: Tg(Thy1-SNCA*)37Dett Location: unknown
• Alliance: Tg(Thy1-SNCA*)37Dett page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-SNCA*)37Dett expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Tg(Thy1-SNCA*)37Dett expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Thy1 (MGI:98747)

• Mutation details: Full-length human SCNA cDNA was mutagenized to carry G51D (nucleotide change: GGT to GAT in exon 3), V40D1 (nucleotide change GTT to GAT in exon 2), and V66D (nucleotide change GTA to GAT in exon 4) mutations placed under the control of the mouse Thy1 neuronal promoter. (J:348676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:348676 Nuber S, et al., Generation of G51D and 3D mice reveals decreased alpha-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinsons Dis. 2024;10(1)
• All: 1 reference(s)