Hmgxb4^tm1Zhji
Targeted Allele Detail

Summary

• Symbol: Hmgxb4^tm1Zhji
• Name: HMG box domain containing 4; targeted mutation 1, Jiliang Zhou
• MGI ID: MGI:7643689
• Synonyms: Hmgxb4^neo
• Gene: Hmgxb4 Location: Chr8:75720305-75758606 bp, + strand Genetic Position: Chr8, 35.57 cM
• Alliance: Hmgxb4^tm1Zhji page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302603
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A gene trap consisting of a loxP site, an FRT flanked-cassette containing En2 spicing acceptor, IRES, lacZ, pA, hBactP, neomycin resistance gene, and pA, followed by exons 3 to 5, and a second loxP site was inserted after exon 2. Transcription of the endogenous gene is expected to be prematurely terminated, while the inserted lacZ reporter gene will be turned on under the endogenous gene promoter. (J:302603)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgxb4 Mutation: 66 strains or lines available

References

• Original: J:302603 He X, et al., Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2021862118
• All: 1 reference(s)