Cyp2a12^em1Utr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cyp2a12^em1Utr
• Name: cytochrome P450, family 2, subfamily a, polypeptide 12; endonuclease-mediated mutation 1, University of Tsukuba Laboratory Animal Resource Center
• MGI ID: MGI:7643808
• Gene: Cyp2a12 Location: Chr7:26728515-26736243 bp, + strand Genetic Position: Chr7, 15.77 cM
• Alliance: Cyp2a12^em1Utr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1,927 bp deletion encompassing exons 3-4. Founder 4 was used to generate this line. (J:302190)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2a12 Mutation: 36 strains or lines available

References

• Original: J:302190 Honda A, et al., Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition. J Lipid Res. 2020 Jan;61(1):54-69
• All: 1 reference(s)