Cyp2c70^em1Utr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cyp2c70^em1Utr
• Name: cytochrome P450, family 2, subfamily c, polypeptide 70; endonuclease-mediated mutation 1, University of Tsukuba Laboratory Animal Resource Center
• MGI ID: MGI:7643809
• Gene: Cyp2c70 Location: Chr19:40141805-40175730 bp, - strand Genetic Position: Chr19, 34.24 cM, cytoband C3
• Alliance: Cyp2c70^em1Utr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1,272 bp deletion encompassing exon 2. Founder 19 was used to generate this line. (J:302190)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2c70 Mutation: 38 strains or lines available

References

• Original: J:302190 Honda A, et al., Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition. J Lipid Res. 2020 Jan;61(1):54-69
• All: 1 reference(s)