Tac2^em2Ysfk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tac2^em2Ysfk
• Name: tachykinin 2; endonuclease-mediated mutation 2, Yoshinori Fukui
• MGI ID: MGI:7643915
• Synonyms: Tac2^- (delta12)
• Gene: Tac2 Location: Chr10:127560347-127567637 bp, + strand Genetic Position: Chr10, 74.81 cM, cytoband D3
• Alliance: Tac2^em2Ysfk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 15 bp (CGTGGGTAGGACGAG) deletion in exon 4, resulting in a frame-shift in the last amino acid sequence encoded by exon 4. (J:305132)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tac2 Mutation: 18 strains or lines available

References

• Original: J:305132 Sakata D, et al., Selective role of neurokinin B in IL-31-induced itch response in mice. J Allergy Clin Immunol. 2019 Oct;144(4):1130-1133.e8
• All: 1 reference(s)