Xaf1^em1Gaod
Endonuclease-mediated Allele Detail

Summary

• Symbol: Xaf1^em1Gaod
• Name: XIAP associated factor 1; endonuclease-mediated mutation 1, Daming Gao
• MGI ID: MGI:7645252
• Gene: Xaf1 Location: Chr11:72192455-72204559 bp, + strand Genetic Position: Chr11, 43.99 cM
• Alliance: Xaf1^em1Gaod page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9 mediated recombination using guide RNAs targeting exon 2 created a 77 bp deletion. (J:338549)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xaf1 Mutation: 18 strains or lines available

References

• Original: J:338549 Chen M, et al., Identification of XAF1 as an endogenous AKT inhibitor. Cell Rep. 2023 Jul 25;42(7):112690
• All: 1 reference(s)