Rnd2^tm1.1Jya
Targeted Allele Detail

Summary

• Symbol: Rnd2^tm1.1Jya
• Name: Rho family GTPase 2; targeted mutation 1.1, Junji Yamauchi
• MGI ID: MGI:7645342
• Synonyms: Rnd2^fl
• Gene: Rnd2 Location: Chr11:101359001-101362679 bp, + strand Genetic Position: Chr11, 65.12 cM, cytoband C-D
• Alliance: Rnd2^tm1.1Jya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309719
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT-flanked neomycin resistance gene and second loxP site were inserted downstream of exon 5. The neomycin resistance gene was removed via flp-mediated recombination, leaving exons 1-5 floxed. (J:309719)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnd2 Mutation: 53 strains or lines available

References

• Original: J:309719 Miyamoto Y, et al., Rnd2 differentially regulates oligodendrocyte myelination at different developmental periods. Mol Biol Cell. 2021 Apr 15;32(8):769-787
• All: 1 reference(s)