Tracem1(Tcrb,Tcra)Strom
Endonuclease-mediated Allele Detail
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Symbol: |
Tracem1(Tcrb,Tcra)Strom |
Name: |
T cell receptor alpha constant; endonuclease-mediated mutation 1, Ingunn Stromnes |
MGI ID: |
MGI:7645418 |
Synonyms: |
1045 TRex |
Gene: |
Trac Location: Chr14:54457978-54461655 bp, + strand Genetic Position: Chr14, 27.7 cM
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Alliance: |
Tracem1(Tcrb,Tcra)Strom page
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Allele Type: |
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Endonuclease-mediated (Inserted expressed sequence, Null/knockout) |
Mutation: |
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Insertion
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Tracem1(Tcrb,Tcra)Strom expresses
2 genes
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Mutation details: CRISPR technology was used to introduce an in-frame, high affinity (clone 1045), codon-optimized, Msln406-414:H-2Db-specific Valpha4/Vbeta9 T cell receptor (TCR) clone 1045 consisting of TCRb variable (V), TCRb constant (C) and TCRa V, linked by a self-cleaving P2A element to exon 1 of the mouse Trac gene and simultaneously delete 23 bp from the 5 end of exon 4 of the endogenous Msln gene to create a knock-out allele.
(J:333043)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trac Mutation: |
6 strains or lines available
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Original: |
J:333043 Rollins MR, et al., Germline T cell receptor exchange results in physiological T cell development and function. Nat Commun. 2023 Feb 1;14(1):528 |
All: |
1 reference(s) |
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