Camk2n1^em1Lyg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Camk2n1^em1Lyg
• Name: calcium/calmodulin-dependent protein kinase II inhibitor 1; endonuclease-mediated mutation 1, Yi-Gang Li
• MGI ID: MGI:7645440
• Gene: Camk2n1 Location: Chr4:138182459-138187437 bp, + strand Genetic Position: Chr4, 70.3 cM
• Alliance: Camk2n1^em1Lyg page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 2828 bp deletion in exons 1-2. Western blot analysis confirmed absence of protein. (J:313857)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2n1 Mutation: 9 strains or lines available

References

• Original: J:313857 Wei Z, et al., Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation. Free Radic Biol Med. 2021 May 1;167:243-257
• All: 1 reference(s)