Gt(ROSA)26Sor^{tm1(CAG-Plgrkt)Lmls}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Plgrkt)Lmls}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Lindsey Miles
• MGI ID: MGI:7645446
• Synonyms: Rosa26 PlgRKT
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Plgrkt)Lmls} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:348802
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Plgrkt)Lmls} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Plgrkt (MGI:1915009)

• Mutation details: The targeting vector was designed with (from 5' to 3') a ubiquitously expressed CAG promoter, a loxP-flanked stop cassette containing a neomycin resistance (neo) cassette, and plasminogen receptor, C-terminal lysine transmembrane, plasminogen receptor KT (Plgrkt) cDNA sequence followed by a bovine growth hormone polyadenylation signal (BGHpA) and 2xSV40pA sequences. This targeting vector was inserted into the Gt(ROSA)26Sor locus. (J:348802)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 958 strains or lines available

References

• Original: J:348802 Miles LA, et al., Overexpression of Plg-R(KT) protects against adipose dysfunction and dysregulation of glucose homeostasis in diet-induced obese mice. Adipocyte. 2023 Dec;12(1):2252729
• All: 1 reference(s)