Isg20^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Isg20^em1Cya
• Name: interferon-stimulated protein; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7645451
• Synonyms: Isg20^em1(flox)Cya
• Gene: Isg20 Location: Chr7:78563172-78570144 bp, + strand Genetic Position: Chr7, 44.84 cM
• Alliance: Isg20^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 mediated recombination inserted loxP sites around a genomic region including exons 3 and 4. (J:343183)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isg20 Mutation: 20 strains or lines available

References

• Original: J:343183 Jia M, et al., Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury. Mol Ther. 2023 Oct 4;31(10):3034-3051
• All: 1 reference(s)