Aspscr1^tm1.1Jsbo
Targeted Allele Detail

Summary

• Symbol: Aspscr1^tm1.1Jsbo
• Name: ASPSCR1 tether for SLC2A4, UBX domain containing; targeted mutation 1.1, Jonathan S Bogan
• MGI ID: MGI:7645890
• Synonyms: Tug^fl
• Gene: Aspscr1 Location: Chr11:120563878-120600273 bp, + strand Genetic Position: Chr11, 84.41 cM, cytoband E2
• Alliance: Aspscr1^tm1.1Jsbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308358
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Targeting vector from IKMC Project CSD30881 composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 5. The critical exon 5 is thus flanked by loxP sites. The lacZ sequence and selection cassette were removed via flp-mediated recombination, leaving exon 5 floxed. (J:308358)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aspscr1 Mutation: 53 strains or lines available

References

• Original: J:308358 Habtemichael EN, et al., Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Nat Metab. 2021 Mar;3(3):378-393
• All: 1 reference(s)