Hapstr1^tm1.2Menm
Targeted Allele Detail

Summary

• Symbol: Hapstr1^tm1.2Menm
• Name: HUWE1 associated protein modifying stress responses; targeted mutation 1.2, Marc L Mendillo
• MGI ID: MGI:7645942
• Gene: Hapstr1 Location: Chr16:8647964-8676786 bp, + strand Genetic Position: Chr16, 4.37 cM, cytoband A3
• Alliance: Hapstr1^tm1.2Menm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:348964
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted around exons 1 and 2 and FRT flanked selection cassettes were inserted via homologous recombination. Flp mediated recombination removed the selection cassettes. Cre mediated recombination removed exons 1 and 2. (J:348964)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hapstr1 Mutation: 38 strains or lines available

References

• Original: J:348964 Amici DR, et al., Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life. Life Sci Alliance. 2024 May;7(5)
• All: 1 reference(s)