Neurl3^em1Luda
Endonuclease-mediated Allele Detail

Summary

• Symbol: Neurl3^em1Luda
• Name: neuralized E3 ubiquitin protein ligase 3; endonuclease-mediated mutation 1, Dan Lu
• MGI ID: MGI:7646922
• Gene: Neurl3 Location: Chr1:36303683-36313755 bp, - strand Genetic Position: Chr1, 15.18 cM
• Alliance: Neurl3^em1Luda page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs inserted a T in exon 2 creating a frameshift mutation. Immunoblot analysis of lungs from homozygous mice confirmed loss of protein expression. (J:344721)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurl3 Mutation: 11 strains or lines available

References

• Original: J:344721 Qi F, et al., E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7. FASEB J. 2022 Aug;36(8):e22409
• All: 1 reference(s)