Ninj2^em1Cqxu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ninj2^em1Cqxu
• Name: ninjurin 2; endonuclease-mediated mutation 1, Chengqi Xu
• MGI ID: MGI:7646979
• Gene: Ninj2 Location: Chr6:120070315-120177300 bp, + strand Genetic Position: Chr6, 56.9 cM, cytoband F1
• Alliance: Ninj2^em1Cqxu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN technology introduced a 1-bp deletion in exon 2 which is predicted to cause termination of the protein after 22 amino acids from the initial methionine. Western blot analysis confirmed the absence of protein expression. (J:332575)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ninj2 Mutation: 24 strains or lines available

References

• Original: J:332575 Peng H, et al., NINJ2 deficiency inhibits preadipocyte differentiation and promotes insulin resistance through regulating insulin signaling. Obesity (Silver Spring). 2023 Jan;31(1):123-138
• All: 1 reference(s)