Rnf122^em1Caox
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnf122^em1Caox
• Name: ring finger protein 122; endonuclease-mediated mutation 1, Xuetao Cao
• MGI ID: MGI:7647313
• Gene: Rnf122 Location: Chr8:31601848-31621510 bp, + strand Genetic Position: Chr8, 17.97 cM
• Alliance: Rnf122^em1Caox page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9 mediated recombination using guide RNAs created a 157 bp deletion of exon 2. (J:344769)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf122 Mutation: 15 strains or lines available

References

• Original: J:344769 Wang W, et al., RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9581-6
• All: 1 reference(s)