Rnd2^tm1.1Fgu
Targeted Allele Detail

Summary

• Symbol: Rnd2^tm1.1Fgu
• Name: Rho family GTPase 2; targeted mutation 1.1, Francois Guillemot
• MGI ID: MGI:7647328
• Synonyms: Rnd2^flox
• Gene: Rnd2 Location: Chr11:101359001-101362679 bp, + strand Genetic Position: Chr11, 65.12 cM, cytoband C-D
• Alliance: Rnd2^tm1.1Fgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:344858
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT-flanked neo cassette were inserted downstream of exon 5 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:344858)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnd2 Mutation: 53 strains or lines available

References

• Original: J:344858 Kerloch T, et al., The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis. Mol Psychiatry. 2021 Dec;26(12):7280-7295
• All: 1 reference(s)