Il31^tm1.1Snak
Targeted Allele Detail

Summary

• Symbol: Il31^tm1.1Snak
• Name: interleukin 31; targeted mutation 1.1, Susumu Nakae
• MGI ID: MGI:7647341
• Synonyms: Il31^egfp
• Gene: Il31 Location: Chr5:123618215-123620686 bp, - strand Genetic Position: Chr5, 63.0 cM, cytoband F
• Alliance: Il31^tm1.1Snak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263831
• Parent Cell Line: EGR-101 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A replacement of the region from a part of exon 2 to a part of the intron 3' to exon 3 with a cassette consisting of IRES-EGFP and a neomycin resistance gene, flanked by loxP sequences. The neomycin cassette was removed via Cre-mediated recombination. qPCR analysis showed mRNA expression below the limit of detection in lung tissue and in PMA-ionomycin-stimulated spleen cells from homozygous mutant mice. (J:263831)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il31 Mutation: 13 strains or lines available

References

• Original: J:263831 Takamori A, et al., IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Sci Rep. 2018 Apr 27;8(1):6639
• All: 2 reference(s)