Ormdl1^em1Pdra
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ormdl1^em1Pdra
• Name: ORM1-like 1 (S. cerevisiae); endonuclease-mediated mutation 1, Petr Draber
• MGI ID: MGI:7647342
• Gene: Ormdl1 Location: Chr1:53336254-53349404 bp, + strand Genetic Position: Chr1, 26.99 cM
• Alliance: Ormdl1^em1Pdra page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate an 85 base pair deletion within the second exon leading to a frameshift mutation. (J:349248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ormdl1 Mutation: 15 strains or lines available

References

• Original: J:349248 Demkova L, et al., Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation. Sci Rep. 2023 Jun 14;13(1):9615
• All: 2 reference(s)