Igs2^{em8(Krt18-ACE2,-cre/ERT2)Cya}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em8(Krt18-ACE2,-cre/ERT2)Cya}
• Name: intergenic site 2; endonuclease-mediated mutation 8, Cyagen Biosciences
• MGI ID: MGI:7657273
• Synonyms: Igs2^{em1(K18-hACE2-2A-CreERT2)}
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em8(Krt18-ACE2,-cre/ERT2)Cya} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Inserted expressed sequence, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Igs2^{em8(Krt18-ACE2,-cre/ERT2)Cya} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Igs2^{em8(Krt18-ACE2,-cre/ERT2)Cya} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt18 (MGI:96692)

• Mutation details: The K18 promoter-Kozak-human ACE2 CDS-P2A-CreERT2-rBG pA gene expression element was inserted into the H11 safety harbor in C57BL/6JCya mice. (J:326541)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt18 (mouse) Summary of all recombinase alleles driven by Krt18. Alliance mouse Krt18 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)