Ifrd2^tm1.1Lah
Targeted Allele Detail

Summary

• Symbol: Ifrd2^tm1.1Lah
• Name: interferon-related developmental regulator 2; targeted mutation 1.1, Lukas A Huber
• MGI ID: MGI:7657419
• Gene: Ifrd2 Location: Chr9:107464917-107470237 bp, + strand Genetic Position: Chr9, 58.24 cM
• Alliance: Ifrd2^tm1.1Lah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:344868
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site and FRT-flanked neo cassette were inserted upstream of exon 1 and a second loxP site, 15 additional nucleotides, part of intron 1, exon 2, and hrGFP were inserted downstream of the endogenous polyA signal. Cre mediated recombination removed the gene and neo cassette. (J:344868)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifrd2 Mutation: 28 strains or lines available

References

• Original: J:344868 Vietor I, et al., The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15). Elife. 2023 Aug 21;12
• All: 1 reference(s)