Trim66^em2Emr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim66^em2Emr
• Name: tripartite motif-containing 66; endonuclease-mediated mutation 2, EMBL Rome
• MGI ID: MGI:7657543
• Synonyms: Trim66^em2(phd)Emr, Trim66^phd
• Gene: Trim66 Location: Chr7:109048213-109107341 bp, - strand Genetic Position: Chr7, 57.21 cM
• Alliance: Trim66^em2Emr page

Mutation origin

• Strain of Origin: C57BL/6JCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted a stop codon in-frame in exon 15 at genomic position 109,056,838 (GRCm39). Western blot analysis confirmed the absence of protein in testis of homozygotes. (J:349240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim66 Mutation: 58 strains or lines available

References

• Original: J:349240 Mielnicka M, et al., Trim66's paternal deficiency causes intrauterine overgrowth. Life Sci Alliance. 2024 Jul;7(7)
• All: 1 reference(s)