Ctps1tm1d(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Ctps1tm1d(KOMP)Wtsi |
Name: |
cytidine 5'-triphosphate synthase 1; targeted mutation 1d, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:7657752 |
Synonyms: |
Ctps1ko |
Gene: |
Ctps1 Location: Chr4:120397065-120427473 bp, - strand Genetic Position: Chr4, 56.52 cM
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Alliance: |
Ctps1tm1d(KOMP)Wtsi page
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Germline Transmission: |
Earliest citation of germline transmission:
J:348981
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 120419414 of Chromosome 4 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4 at position 120420614. The critical exon 4 is thus flanked by loxP sites. The lacZ and neomycin resistance gene were removed via flp-mediated recombination. Exon 4 was deleted via cre-mediated recombination generating a knock-out allele.
(J:348981)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ctps1 Mutation: |
46 strains or lines available
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Original: |
J:348981 Soudais C, et al., Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice. Nat Commun. 2024 Mar 4;15(1):1982 |
All: |
1 reference(s) |
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