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Ctps1tm1d(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Ctps1tm1d(KOMP)Wtsi
Name: cytidine 5'-triphosphate synthase 1; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:7657752
Synonyms: Ctps1ko
Gene: Ctps1  Location: Chr4:120397065-120427473 bp, - strand  Genetic Position: Chr4, 56.52 cM
Alliance: Ctps1tm1d(KOMP)Wtsi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:348981
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 120419414 of Chromosome 4 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4 at position 120420614. The critical exon 4 is thus flanked by loxP sites. The lacZ and neomycin resistance gene were removed via flp-mediated recombination. Exon 4 was deleted via cre-mediated recombination generating a knock-out allele. (J:348981)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctps1 Mutation:  46 strains or lines available
References
Original:  J:348981 Soudais C, et al., Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice. Nat Commun. 2024 Mar 4;15(1):1982
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory