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Ctps2tm1c(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Ctps2tm1c(EUCOMM)Hmgu
Name: cytidine 5'-triphosphate synthase 2; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:7657753
Synonyms: Ctps2flox
Gene: Ctps2  Location: ChrX:161684234-161815504 bp, + strand  Genetic Position: ChrX, 75.09 cM, cytoband F5
Alliance: Ctps2tm1c(EUCOMM)Hmgu page
IMPC: Ctps2 gene page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:348981
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe L1L2_GT0_LF2A_LacZ_BetactP_neo cassette was inserted at position 161708956 of Chromosome X upstream of the critical exon 8 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 8 at position 161710712. The critical exon 8 is thus flanked by loxP sites. The lacZ and neomycin resistance gene were removed via flp-mediated recombination generating a conditional ready exon 8 floxed allele. (J:348981)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctps2 Mutation:  17 strains or lines available
References
Original:  J:348981 Soudais C, et al., Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice. Nat Commun. 2024 Mar 4;15(1):1982
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory