Ctps2tm1c(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Ctps2tm1c(EUCOMM)Hmgu |
Name: |
cytidine 5'-triphosphate synthase 2; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:7657753 |
Synonyms: |
Ctps2flox |
Gene: |
Ctps2 Location: ChrX:161684234-161815504 bp, + strand Genetic Position: ChrX, 75.09 cM, cytoband F5
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Alliance: |
Ctps2tm1c(EUCOMM)Hmgu page
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IMPC: |
Ctps2 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:348981
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: The L1L2_GT0_LF2A_LacZ_BetactP_neo cassette was inserted at position 161708956 of Chromosome X upstream of the critical exon 8 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 8 at position 161710712. The critical exon 8 is thus flanked by loxP sites. The lacZ and neomycin resistance gene were removed via flp-mediated recombination generating a conditional ready exon 8 floxed allele.
(J:348981)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ctps2 Mutation: |
17 strains or lines available
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Original: |
J:348981 Soudais C, et al., Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice. Nat Commun. 2024 Mar 4;15(1):1982 |
All: |
1 reference(s) |
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