Il11^tm2.1Moto
Targeted Allele Detail

Summary

• Symbol: Il11^tm2.1Moto
• Name: interleukin 11; targeted mutation 2.1, Toshio Matsumoto
• MGI ID: MGI:7659210
• Synonyms: IL-11^fl
• Gene: Il11 Location: Chr7:4775372-4785858 bp, - strand Genetic Position: Chr7, 2.76 cM
• Alliance: Il11^tm2.1Moto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345337
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neomycin cassette were inserted upstream of exon 4 and second loxP site was inserted downstream of exon 4. The neomycin cassette was removed via flp-mediated recombination leaving exon 4 floxed. (J:345337)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il11 Mutation: 21 strains or lines available

References

• Original: J:345337 Dong B, et al., Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis. Nat Commun. 2022 Nov 23;13(1):7194
• All: 1 reference(s)