Btbd8^em1Lych
Endonuclease-mediated Allele Detail

Summary

• Symbol: Btbd8^em1Lych
• Name: BTB domain containing 8; endonuclease-mediated mutation 1, Lingyi Chen
• MGI ID: MGI:7660970
• Gene: Btbd8 Location: Chr5:107585863-107659073 bp, + strand Genetic Position: Chr5, 52.23 cM
• Alliance: Btbd8^em1Lych page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9 mediated recombination using guide RNAs targeting exon 14 created a deletion of exon 14. (J:349252)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Btbd8 Mutation: 10 strains or lines available

References

• Original: J:349252 Yang X, et al., Btbd8 deficiency reduces susceptibility to colitis by enhancing intestinal barrier function and suppressing inflammation. Front Immunol. 2024;15:1382661
• All: 1 reference(s)