Aldh1a1^{em1(icre)Awar}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Aldh1a1^{em1(icre)Awar}
• Name: aldehyde dehydrogenase family 1, subfamily A1; endonuclease-mediated mutation 1, Rajeshwar Awatramani
• MGI ID: MGI:7661041
• Synonyms: Aldh1a1-iCre
• Gene: Aldh1a1 Location: Chr19:20470079-20620829 bp, + strand Genetic Position: Chr19, 13.91 cM
• Alliance: Aldh1a1^{em1(icre)Awar} page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Aldh1a1^{em1(icre)Awar} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aldh1a1 (MGI:1353450)

• Mutation details: CRISPR/cas9 mediated recombination inserted a construction containing a P2A peptide, icre gene, and BGH polyA sequence after the last encoded amino acid. (J:349179)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aldh1a1 (mouse) Summary of all recombinase alleles driven by Aldh1a1. Alliance mouse Aldh1a1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aldh1a1 Mutation: 37 strains or lines available

References

• Original: J:349179 Azcorra M, et al., Unique functional responses differentially map onto genetic subtypes of dopamine neurons. Nat Neurosci. 2023 Oct;26(10):1762-1774
• All: 1 reference(s)