Pias3^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pias3^em1Cya
• Name: protein inhibitor of activated STAT 3; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7662566
• Gene: Pias3 Location: Chr3:96603700-96613386 bp, + strand Genetic Position: Chr3, 41.95 cM
• Alliance: Pias3^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting exons 2-9 created a null allele. Quantitative RT-PCR and western blot analysis confirmed the absence of expression in homozygous mice. (J:345238)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pias3 Mutation: 39 strains or lines available

References

• Original: J:345238 Fu W, et al., Genetic deficiency of protein inhibitor of activated STAT3 suppresses experimental abdominal aortic aneurysms. Front Cardiovasc Med. 2023;10:1092555
• All: 1 reference(s)