Tspyl5^em1Yuya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tspyl5^em1Yuya
• Name: testis-specific protein, Y-encoded-like 5; endonuclease-mediated mutation 1, Yuan Yang
• MGI ID: MGI:7665244
• Gene: Tspyl5 Location: Chr15:33684021-33688029 bp, - strand Genetic Position: Chr15, 13.91 cM
• Alliance: Tspyl5^em1Yuya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted 1994 bp (chr15:3368606333688056, grcm38/mm10) including the untranslated region and whole coding sequence. RT-qPCR confirmed absence of mRNA expression in various tissues. (J:350814)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspyl5 Mutation: 15 strains or lines available

References

• Original: J:350814 Leng X, et al., Mouse Tspyl5 promotes spermatogonia proliferation through enhancing Pcna-mediated DNA replication. Reprod Fertil Dev. 2024 Jan;36
• All: 1 reference(s)