Lpar6^tm1.1Bcz
Targeted Allele Detail

Summary

• Symbol: Lpar6^tm1.1Bcz
• Name: lysophosphatidic acid receptor 6; targeted mutation 1.1, Bogdan Czerniak
• MGI ID: MGI:7665329
• Gene: Lpar6 Location: Chr14:73475331-73477798 bp, + strand Genetic Position: Chr14, 38.75 cM
• Alliance: Lpar6^tm1.1Bcz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350956
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the entire exon of Lpar6, and an FRT-flanked PGK-neo cassette and second loxP site were inserted downstream of the entire exon. Cre-mediated recombination removed the entire exon, including the 5UTR and 3UTR) of the gene and the PGK-neo. (J:350956)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpar6 Mutation: 31 strains or lines available

References

• Original: J:350956 Lee S, et al., Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis. Cell Rep. 2024 May 28;43(5):114146
• All: 1 reference(s)