Cd79b^tm1.1Rein
Targeted Allele Detail

Summary

• Symbol: Cd79b^tm1.1Rein
• Name: CD79B antigen; targeted mutation 1.1, H Christian Reinhardt
• MGI ID: MGI:7666002
• Synonyms: Cd79b^c-p.Y195H
• Gene: Cd79b Location: Chr11:106202167-106205388 bp, - strand Genetic Position: Chr11, 68.89 cM
• Alliance: Cd79b^tm1.1Rein page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:351007
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector was designed to insert a loxP site followed by a frt-flanked neomycin resistance (neo) cassette upstream of the endogenous exon 3 of the CD79B antigen (Cd79b) gene. A polyadenylation (pA) site followed by an F3-flanked puromycin resistance (puro) cassette and a second loxP site was inserted downstream of endogenous exon 6. Following the second loxP site, a region containing exons 3-6, with a mutant exon 5, was inserted. Specifically, the mutant exon 5 has a TAT to CAC missense mutation inserted at position 195 of Cd79b. This results in the tyrosine to histidine mutation Y195H, analogous to Y196H in humans. The election cassettes were removed by crossing to to FLPe transgenic mice. (J:351007)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd79b Mutation: 36 strains or lines available

References

• Original: J:351007 Flumann R, et al., An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma. Blood Adv. 2024 Mar 12;8(5):1063-1074
• All: 1 reference(s)